Effects of dihydropyridine CGP on currents through the calcium channels in frog skeletal muscle.
نویسندگان
چکیده
CGP
منابع مشابه
Voltage dependent ionic currents in frog cultured skeletal myocytes.
The voltage dependent ionic currents in cultured embryonic skeletal myocytes at stages of development ranging from 1 to 6 day were studied using the whole-cell patch clamp technique. Sodium (INa) and calcium (ICa) inward and potassium (IK) outward currents were observed at all stages. INa did not differ from that described in adult frog striated muscle fibres. Slow ICa was mediated by current t...
متن کاملThe effects of calcium channel modulators on contractions of tonic frog muscle fibres.
Effects of adrenaline (ADR) and the dihydropyridine Ca channel agonist CGP-IOS were studied on twitch and tetanic contractions of isolated tonic muscle fibres or small muscle fibre bundles containing tonic fibres of the frog Rana temporaria. Tetanization caused a gradual increase of tension between 10 and 70 Hz. CGP-IOS produced an increase in twitch amplitude. After CGP-IOS administration (2 x...
متن کاملFunctional properties of cardiac L-type calcium channels transiently expressed in HEK293 cells. Roles of alpha 1 and beta subunits
The cardiac dihydropyridine-sensitive calcium channel was transiently expressed in HEK293 cells by transfecting the rabbit cardiac calcium channel alpha 1 subunit (alpha 1C) alone or in combination with the rabbit calcium channel beta subunit cloned from skeletal muscle. Transfection with alpha 1C alone leads to the expression of inward, voltage-activated, calcium or barium currents that exhibi...
متن کاملDihydropyridine actions on calcium currents of frog sympathetic neurons.
Dihydropyridines (DHPs) generally have little effect on whole-cell calcium currents of neurons, even at concentrations far higher than those effective on muscle. Either neuronal calcium currents are much less sensitive to DHPs, or only a small proportion of the current is DHP-sensitive. We find that DHP agonists and antagonists act at low concentration on calcium currents in frog sympathetic ne...
متن کاملDihydropyridine receptors are primarily functional L-type calcium channels in rabbit ventricular myocytes.
We measured [3H]PN200-110 binding and patch-clamp currents in rabbit ventricular myocytes to determine if there is a disparity between the density of dihydropyridine-specific receptors and functional L-type calcium channels, as has been reported for skeletal muscle. The dihydropyridine receptor density was 74.7 +/- 4.2 fmol/mg protein (mean +/- SEM, Kd = 1.73 +/- 0.29 nM, n = 6) in ventricular ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- General physiology and biophysics
دوره 9 1 شماره
صفحات -
تاریخ انتشار 1990